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Sunday, October 26, 2008 6:30-9:00 PM, Welcoming reception, Georgia Center for Continuing Education
Monday, October 27, 2008 8:45-9:00 AM Opening remarks: Robert S. Phillips, University of Georgia, USA; Heidi Davison, Mayor of Athens 9:00-9:45 AM Nigel Scrutton, University of Manchester, UK, “Isotope Effects and Driving Force Studies of Proton Tunneling in Aromatic Amine Dehydrogenase” Coffee break, 9:45-10:00 AM 10:00 AM-12:00 PM Scientific sessions Pyridoxal-5'-phosphate dependent enzymes (Chair, Andrea Mozzarelli) 10:00-10:30 AM John Richard, University at Buffalo, New York, USA, “Model Studies on Cofactor Catalysis: PLP and Simple Ketones” 10:40-11:10 AM Gregory Hunter, University of South Florida, Florida, USA, “The remarkable molecular mechanisms underlying 5-aminolevulinate synthase catalysis” 11:20-11:50 AM Mita Bertoldi, University of Verona, Italy, “Insights into the Mechanism of Oxidative Deamination Catalyzed by DOPA Decarboxylase” Quinones and quinoproteins (Chair, Katsu Tanizawa) 10:00-10:30 AM Stephen R. Wecklser, University of California, Berkeley, USA, “PQQ biogenesis: Demonstration of Enzyme Activity for PqqE and its Relationship to PqqD” 10:40-11:10 AM Sandra Puehringer, University of Salzburg, Austria, “Structural studies of the cofactorless oxidase PqqC” 11:20-11:50 AM Carrie Wilmot, University of Minnesota, USA, “MauG: an enzyme involved in the biosynthesis of the tryptophan tryptophylquinone cofactor of methylamine dehydrogenase” 12:00-2:00 PM lunch and poster sessions: Pyridoxal-5'-phosphate dependent enzymes; Quinones and quinoproteins 2:00-6:00 PM Scientific sessions Pyridoxal-5'-phosphate dependent enzymes (Chair, Mita Bertoldi) 2:00-2:30 PM Andrea Mozzarelli, University of Parma, Italy, “O-Acetylserine Sulfhydrylase and Serine Acetyltransferase: from Protein-Protein Interactions to Novel Antimicrobial Agents” 2:40-3:10 PM Dalibor Milić, University of Zagreb, Croatia, “Structural Studies of the Enzymatic Mechanism of Citrobacter freundii Tyrosine Phenol-lyase” 3:10-3:40 PM Coffee break 3:40-4:10 PM Aaron Rabinkov, Weizmann Institute of Science, Israel, “Thiol-disulfide organization in alliin lyase (alliinase) from garlic (Allium sativum)” 4:20-4:50 PM Robert Phillips, University of Georgia, USA, “The Crystal Structure of the Pseudomonas dacunhae Aspartate-Beta-Decarboxylase Reveals a Novel Oligomeric Assembly for a Pyridoxal-5’-Phosphate Dependent Enzyme” 5:00-5:30 PM Abraham Parola, Ben-Gurion University of the Negev, Israel, “Reduced Tight Assembly of Trpase Tetramer Enhanced PLP Release Leading to Dissociation and Cold Inactivation” 5:40-6:10 PM Ben Liu, University of Texas, USA, “Mechanistic Studies of C-4 Deoxygenation in the Biosynthesis of Desosamine” Quinones and quinoproteins (Chair, Victor Davidson) 2:00-2:30 PM Katsu Tanizawa, Osaka University, Japan, “Involvement of an Iron Sulfur Protein and a Subtilisin-like Protease in the Posttranslational Modification of Quinohemoprotein Amine Dehydrogenase” 2:40-3:10 PM Hirohide Toyama, University of the Ryukyus, Japan, “Three quinoprotein alcohol dehydrogenases of Pseudomonas putida HK5: Analysis of promoter activities” 3:10-3:30 Coffee break 3:40-4:10 PM Mamoru Yamada, Yamaguchi University, Japan, “Menaquinone as well as ubiquinone as a bound quinone crucial for catalytic activity and intramolecular electron transfer in Escherichia coli quinoprotein glucose dehydrogenase” 4:20-4:50 PM Koji Sode, Tokyo University of Agriculture & Technology, Japan, “The Cutting Edge in the Biomolecular Engineering of Pyrroloquinoline Quinone Glucose Dehydrogenases and Their Industrial Application” 5:00-5:30 PM Sam Hay, University of Manchester, UK, “Hydrostatic Pressure: A New Probe of Promoting Motions in Enzyme Catalysis” 6:30-8:30 PM Dinner
Tuesday, October 28, 2008 9:00-9:45 AM, Hideyuki Hayashi, Osaka Medical College, Japan, “Substrate- and Product-Assisted Catalysis and Reaction Specificity in Pyridoxal Enzymes” Coffee break, 9:45-10:00 AM 10:00 AM-12:00 PM Scientific sessions Pyridoxal-5'-phosphate dependent enzymes (Chair, Aaron Rabinkov) 10:00-10:30 AM Tohru Yoshimura, Nagoya University, Japan, “Role of Pyridoxal 5’-Phosphate of GabR, a Transcriptional Regulator of Bacillus subtilis” 10:40-11:10 AM Tomokazu Ito, Nagoya University, Japan, “A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae: Identification and application” 11:20-11:50 AM Tathagata Mukerjee, Cornell University, USA, “Identification and characterization of PLP catabolic genes in Mesorhizobium loti MAFF303099” Flavoenzymes and pterins (Chair, Giovanni Gadda) 10:00-10:30 AM Russ Hille, University of California, Riverside, USA, “The reaction mechanism of xanthine oxidoreductase” 10:40-11:10 AM Denis J. Stuehr, Cleveland Clinic, USA, “Redox Cycling of Tetrahydrobiopterin within Nitric Oxide Synthase: Mechanisms and Implications for Uncoupled Oxygen Reduction” 11:20-11:50 AM Peter Macheroux, Graz University of Technology, Austria, “Structure and Mechanism of Berberine Bridge Enzyme – a Flavoenzyme with a Bicovalently Linked FAD Cofactor” 12:00-2:00 PM lunch and poster sessions: Biosynthesis of Biofactors; Flavoenzymes and pterins 2:00-6:00 PM Scientific sessions Biosynthesis of Biofactors (Chair, Tadhg Begley) 2:00-2:30 PM Andrei Osterman, Burnham Institute for Medical Research, USA, “Comparative genomics of NAD biosynthesis” 2:40-3:10 PM Ivo Tews, Heidelberg University, Germany, “Vitmain B6 Biosynthesis by a 640 kDa protein complex” 3:10-3:40 PM Coffee break 3:40-4:10 PM Steve Ealick, Cornell University, USA, “Recent Developments in the Structural Biology of Thiamin Biosynthesis” 4:20-4:50 PM Paola Mera, University of Wisconsin, USA, “Structural and Functional Analyses of the Human-type Corrinoid Adenosyltransferase (PduO) from Lactobacillus reuteri” 5:00-5:30 PM Robert H. White, Virginia Tech, USA, “New Anaerobic Routes for Coenzyme Biosynthesis and Their Implications in the Evolution of Life” 5:40-6:10 PM Biswarup Mukhopadhyay, Virginia Tech, USA, “TBA” Flavoenzymes and pterins (Chair, Russ Hille) 2:00-2:30 PM Andrea Mattevi, University of Pavia, Italy, “Investigating the Oxygen Reactivity in Flavoenzymes” 2:40-3:10 PM Giovanni Gadda, Georgia State University, USA, “Enzyme-substrate Preorganization in the Alcohol Oxidation Catalyzed by Choline Oxidase” 3:10-3:40 PM Coffee break 3:40-4:10 PM Kenji Inagaki, Okayama University, Japan, “Molecular Characterization of L-Glutamate Oxidase from Streptomyces sp.” 4:20-4:50 PM Dale Edmondson, Emory University, USA, “The Covalent FAD Environment in Monoamine Oxidase: Influence on Catalysis” 5:00-5:30 PM Leslie Poole, Wake Forest University, USA, “Mechanisms of Catalysis and Thiol-Disulfide Interchange Pathways in AhpF and AhpC of the Bacterial Alkyl Hydroperoxide Reductase System” 5:40-6:10 PM Toshihisa Ohsimia, Kyushu University, Japan, “The functional and structural characteristics of FAD, FMN and ATP-containing dye-linked L-proline dehydrogenase complex from Pyrococcus horikoshii 6:30-8:30 PM Dinner
Wednesday, October 29, 2008 9:00-9:45 AM Victor Davidson, University of Mississippi Medical Center, USA, “Mechanistic Insights into the Biosynthesis of Tryptophan Tryptophylquinone, a Protein-Derived Cofactor” 10:00 AM, Leave for excursion to North Georgia mountains, lunch at Wolf Mountain winery, visit Brasstown Bald mountain after lunch, return 6:00 PM.
Thursday, October 30, 2008 9:00-9:45 AM Amnon Kohen, University of Iowa, USA, “Flavin-dependent thymidylate synthase: The diverse role of FAD” 10:00 AM-12:00 PM Scientific sessions Biosynthesis of Biofactors (Chair, Robert H. White) 10:00-10:30 AM Marc Fontecave, CNRS-CEA-Université Joseph Fourier, France, “Biosynthesis of mineral cofactors: the case of [Fe-S] clusters” 10:40-11:10 AM Petra Haenzelmann, University of Wuerzburg, Germany, “Insights into the Radical-Based Synthesis of Precursor Z,the First Step of Molybdenum Cofactor Biosynthesis”
11:20-11:50 AM Silke Leimkuehler, Universität Potsdam, Germany, “The biosynthesis of the molybdenum cofactor in E. coli and humans: a link to FeS cluster biosynthesis” Flavoenzymes and pterins (Chair, Dale Edmondson) 10:00-10:30 AM Marco Fraaije, University of Groningen, The Netherlands, “Elucidating the role and mechanism of covalent flavinylation” 10:40-11:10 AM Alessandro Aliverti, University of Milano, Italy, “Ferredoxin–NADP+ reductases of Apicomplexa: unique properties of protozoan plant–type enzymes” 11:20-11:50 AM Patrick McTamney, University of Maryland, USA, “Structure of Iodotyrosine Deiodinase: Mechanistic Implications” Biomedical Aspects of Vitamins/Biofactors (Chair, Arthur Cooper) 10:00-10:30 AM Norihisa Kato, Hiroshima University, Japan, “Vitamin B6 Suppresses Autophagy Induced by Nutrient Starvation” 10:40-11:10 AM Tomoko Kayashima, Hiroshima University, Japan, “Dietary Vitamin B6 Suppresses Colon Heat Shock Proteins, Targets for Cancer Therapy, in 1,2-Dimethylhydrazine-treated Rats” 11:20-11:50 AM Shyamala Dakshinamurti, University of Manitoba, Canada, “Pyridoxal Phosphate Binds to L-type Calcium Channels in Vascular Myocytes” 12:00-2:00 PM lunch and poster sessions: Biomedical Aspects of Vitamins/Biofactors 2:00-6:00 PM Scientific sessions: Biomedical Aspects of Vitamins/Biofactors (Chair, K. Dakshinamurti) 2:00-2:30 PM Y. Sone, Ochanomizu University, Japan, “Influence of Dose Level of Vitamin C on the Expression of Vitamin C Transporters in ODS Rats” 2:40-3:10 PM Arthur Cooper, New York Medical College, USA, “Metabolism of Endogenous and Exogenous Electrophiles through the Mercapturate/Cysteine S-conjugate β-Lyase Pathway” 3:10-3:40 PM Coffee break 3:40-4:10 PM Takashi Tamura, Okayama University, Japan, “Selenite Assimilation into Formate Dehydrogenase H depends on Thioredoxin Reductase in Escherichia coli” 4:20-4:50 PM Vincent C.O. Njar, “Novel atypical retinoic acid metabolism agents (RAMBAs) for treatment of cancers” 5:00-5:30 PM Robert Rucker, University of California, Davis, “Pyrroloquinoline Quinone: Physiological Properties and Nutritional Significance” 7:00-10:00 Conference banquet
Friday, October 31, 2008 9:00-9:45 AM, Ronald Eitenmiller, University of Georgia, USA, “Advances in Folic Acid and Folate Research – Nutrition, Fortification and Analysis” 10:00-12:00 AM Scientific sessions Biomedical Aspects of Vitamins/Biofactors (Chair, Robert Rucker) 10:00-10:30 AM Krishnamurti Dakshinamurti, University of Manitoba, Canada, “A microarray study of the effect of biotin repletion on pancreatic gene expression in biotin-deficient rats” 10:40-11:10 AM Paul Voziyan, “Pyridoxamine and diabetic retinopathy” 11:20-11:50 AM Angelo Azzi, “New insights in the Vitamin E mechanism and its protection against human disease” 12:00 PM Closing remarks 12:30-2:00 PM lunch |